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ALOX15B / 15-LOX-2

arachidonate 15-lipoxygenase, type B

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.

Gene Name: arachidonate 15-lipoxygenase, type B
Family/Subfamily: Lipoxygenase , Not assigned-Other
Synonyms: ALOX15B, 15S-lipoxygenase, 15-lipoxygenase 2, 15-LOX-2, 15-LOX-B, Arachidonate 15-lipoxygenase B, Arachidonate 15-lipoxygenase 2
Target Sequences: NM_001141 NP_001132.2 O15296

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Proteins (10)
Over-Expression Lysate (6)
Recombinant (4)
ALOX15B / 15-LOX-2 (10)
No (10)
GST (1)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (6)
Human (6)
Rat (1)
293T Cells (3)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
ALOX15B / 15-LOX-2 Protein - Recombinant Arachidonate-15-Lipoxygenase, Type B By SDS-PAGE
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E. coli
His-T7
30.5 kDa
50 µg/$430; 10 µg/$279; 200 µg/$857; 100 µg/$687; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
ALOX15B / 15-LOX-2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ALOX15B / 15-LOX-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
75.7 kDa
100 µg/$710
ALOX15B / 15-LOX-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
72.3 kDa
20 µg/$215
ALOX15B / 15-LOX-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67.2 kDa
20 µg/$215
ALOX15B / 15-LOX-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
75.7 kDa
20 µg/$215
ALOX15B / 15-LOX-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
72.3 kDa
100 µg/$710
ALOX15B / 15-LOX-2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
67.2 kDa
100 µg/$710
ALOX15B / 15-LOX-2 Protein - Recombinant  Arachidonate-15-Lipoxygenase, Type B By SDS-PAGE
Select
E. coli
His-T7
35.8 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
ALOX15B / 15-LOX-2 Protein - 12.5% SDS-PAGE of human ALOX15B stained with Coomassie Blue
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Wheat Germ Extract
GST
102.3 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).