ALOX15 / 15-Lipoxygenase

arachidonate 15-lipoxygenase

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

ALOX15 / 15-Lipoxygenase (5)

Publications

No (5)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ALOX15 / 15-Lipoxygenase Protein (Recombinant His) (aa170-312) - LS-G13062

Source:

E. coli

Tag:

His

Molecular Weight:

17.6 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human ALOX15 / 15-Lipoxygenase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64974

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.6 kDa

Price:

20 µg/$1,107

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ALOX15 / 15-Lipoxygenase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99340

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.6 kDa

Price:

100 µg/$494

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Human ALOX15 / 15-Lipoxygenase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74569

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.6 kDa

Price:

20 µg/$150

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Human ALOX15 / 15-Lipoxygenase Protein (Recombinant GST) (Full Length) - LS-G27431

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.56 kDa

Price:

10 µg/$479; 25 µg/$670

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