ALOX15 / 15-Lipoxygenase

arachidonate 15-lipoxygenase

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

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Products

ELISA Kits (11)

Type

Custom (3)

Sandwich (7)

Sandwich CLIA (1)

Target

ALOX15 / 15-Lipoxygenase (11)

Reactivity

Human (5)

Guinea pig (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (9)

Publications

No (11)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

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Human ALOX15 / 15-Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F9552

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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Human ALOX15 / 15-Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F23767

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human ALOX15 / 15-Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F36593

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human ALOX15 / 15-Lipoxygenase (Custom ELISA) ELISA Kit - LS-F15402

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human ALOX15 / 15-Lipoxygenase (CLIA) ELISA Kit - LS-F29234

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Guinea pig ALOX15 / 15-Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F41435

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Monkey ALOX15 / 15-Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F41436

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Porcine ALOX15 / 15-Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F41437

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Rabbit ALOX15 / 15-Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F41439

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Pig ALOX15 / 15-Lipoxygenase (Custom ELISA) ELISA Kit - LS-F18909

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Bovine ALOX15 / 15-Lipoxygenase (Custom ELISA) ELISA Kit - LS-F18913

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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