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Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Gene Name: | alkB, alkylation repair homolog 8 (E. coli) |
Synonyms: | ALKBH8, AlkB homologue 8, ABH8 |
Target Sequences: | NM_138775 NP_620130.2 Q96BT7 |
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