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ALKBH7
AlkB, Alkylation Repair Homolog 7 (E. Coli)
Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
| Gene Name: | AlkB, Alkylation Repair Homolog 7 (E. Coli) |
| Synonyms: | ALKBH7, ABH7, SPATA11, UNQ6002, Spermatogenesis associated 11 |
| Target Sequences: | NM_032306 NP_115682.1 Q9BT30 |
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