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ALK3 / BMPR1A

bone morphogenetic protein receptor, type IA

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Gene Name: bone morphogenetic protein receptor, type IA
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: BMPR1A, 10q23del, ALK3, ALK-3, BMP type-1A receptor, BMPR-1A, CD292, CD292 antigen, Activin receptor-like kinase 3, ACVRLK3, SKR5
Target Sequences: NM_004329 NP_004320.2 P36894

Publications (5)

1
Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes. Pache G, Schfer C, Wiesemann S, Springer E, Liebau M, Reinhardt HC, August C, Pavenstdt H, Bek MJ. American journal of physiology. Renal physiology. 2006 291:F654-62. [PubMed:16622178]
2
Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Zhang Y, Mu Q, Zhou H, Vrijens K, Roussel MF, Jiang G, Yan B. Cell death & disease. 2012 3:e308. [PubMed:22573038] [PMC:PMC3366082]
3
A crucial role of bone morphogenetic protein signaling in the wound healing response in acute liver injury induced by carbon tetrachloride. Oumi N, Taniguchi KA, Kanai AM, Yasunaga M, Nakanishi T, Sato K. International journal of hepatology. 2012 2012:476820. [PubMed:22701178] [PMC:PMC3372049] Related Antibodies: LS-C97653.
4
Immunohistological localization of BMP-2, BMP-7, and their receptors in knee joints with focal cartilage lesions. Hagen Schmal, Alexander T Mehlhorn, Ingo H Pilz, David Dovi-Akue, Christina Kirchhoff, Norbert P Südkamp, Ulrike Gerlach, Christian Lohrmann, Philipp Niemeyer. TheScientificWorldJournal. 2012 January;2012:467892. [Full Text Article] [PubMed:22272175] [PMC:PMC3259605] Related Antibodies: LS-C4217.
5
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a beta -catenin-dependent manner. Yang Z, Hai B, Qin L, Ti X, Shangguan L, Zhao Y, Wiggins L, Liu Y, Feng JQ, Chang JY, Wang F, Liu F. Molecular and cellular biology. 2013 Dec;33:4732-44. [Full Text Article] [PubMed:24081330] [PMC:PMC3838012] Related Antibodies: LS-C97656.
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ELISA Kits (19)
Custom (2)
Sandwich (16)
Sandwich CLIA (1)
ALK3 / BMPR1A (19)
Human (5)
Mouse (3)
Rat (5)
Bovine (1)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (15)
No (19)
Cell Lysates (2)
Plasma (9)
Serum (9)
Tissue Homogenates (6)
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$779
ALK3 / BMPR1A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ALK3 / BMPR1A ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ALK3 / BMPR1A ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ALK3 / BMPR1A ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
ALK3 / BMPR1A ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$823
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$822
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$715
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$782
ALK3 / BMPR1A ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).