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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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Additional Contact Details
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ALK-6 / BMPR1B
bone morphogenetic protein receptor, type IB
ALK-6 / BMPR1B is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
| Gene Name: | bone morphogenetic protein receptor, type IB |
| Family/Subfamily: | Protein Kinase , Activin/TGFb |
| Synonyms: | BMPR1B, Activin receptor-like kinase 6, ALK-6, Bmp receptor 1b, Bmp receptor ib, BMP receptor type IB, CDw293, CFK-43a, BMPR-1B, ALK6, Type IB BMPR, BMP type-1B receptor, BMPR-IB, CDw293 antigen, Type IB BMP receptor |
| Target Sequences: | NM_001203 NP_001194.1 O00238 |
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