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ALDH7A1
aldehyde dehydrogenase 7 family, member A1
ALDH7A1 is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.
| Gene Name: | aldehyde dehydrogenase 7 family, member A1 |
| Synonyms: | ALDH7A1, 26g turgor protein homolog, EPD, PDE, Alpha-AASA dehydrogenase, Antiquitin-1, ATQ1, Betaine aldehyde dehydrogenase, p6c dehydrogenase |
| Target Sequences: | NM_001182 NP_001173.2 P49419 |
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