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ALDH1L2

aldehyde dehydrogenase 1 family, member L2

ALDH1L2 encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.

Gene Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: ALDH1L2, MtFDH, Mitochondrial 10-FTHFDH
Target Sequences: NM_001034173 NP_001029345.2 Q3SY69

Publications (2)

1
Oxidative stress inhibits distant metastasis by human melanoma cells. Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. Nature. 2015 527:186-91. (IHC, WB; Human) [Full Text Article] [PubMed:26466563] [PMC:PMC4644103] Related Antibodies: LS-C178510.
2
Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism. Biancur DE, Paulo JA, Malachowska B, Quiles Del Rey M, Sousa CM, Wang X, Sohn ASW, Chu GC, Gygi SP, Harper JW, Fendler W, Mancias JD, Kimmelman AC. Nature communications. 2017 8:15965. (IHC; Human) [Full Text Article] [PubMed:28671190] [PMC:PMC5500878] Related Antibodies: LS-C178510.

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
ALDH1L2 (3)
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GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
ALDH1L2 Protein - 12.5% SDS-PAGE of human ALDH1L2 stained with Coomassie Blue
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Wheat Germ Extract
GST
79.7 kDa
10 µg/$479; 25 µg/$670
ALDH1L2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
101.6 kDa
20 µg/$215
ALDH1L2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
101.6 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).