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AKTIP / FTS
AKT interacting protein
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
| Gene Name: | AKT interacting protein |
| Synonyms: | AKTIP, AKT interacting protein, AKT-interacting protein, FT1, Fused toes (mouse) homolog, Fused toes homolog, Fused toes homolog (mouse), FTS, Fused toes protein homolog |
| Target Sequences: | NM_001012398 NP_001012398.1 Q9H8T0 |
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