AKR1C4 / Chlordecone Reductase

aldo-keto reductase family 1, member C4

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

AKR1C4 / Chlordecone Reductase (8)

Publications

No (8)

Tag

6His, N-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

Biologically Active

Biologically active (1)

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Human AKR1C4 / Chlordecone Reductase Protein (Recombinant His) - LS-G1327

Source:

E. coli

Tag:

His

Biological Activity:

Biologically active

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human AKR1C4 / Chlordecone Reductase Protein (Recombinant 6His, N-terminus) (Met1-Tyr323) - LS-G39564

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.3kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human AKR1C4 / Chlordecone Reductase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87952

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.9 kDa

Price:

20 µg/$150

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Human AKR1C4 / Chlordecone Reductase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70767

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.9 kDa

Price:

20 µg/$1,107

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AKR1C4 / Chlordecone Reductase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118378

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.9 kDa

Price:

100 µg/$494

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Human AKR1C4 / Chlordecone Reductase Protein (Recombinant GST) (Full Length) - LS-G27908

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.27 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AKR1C4 / Chlordecone Reductase Protein (Recombinant GST, N-terminus) (aa1-323) - LS-G56082

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human AKR1C4 / Chlordecone Reductase Protein (Recombinant 6His, N-terminus) (Met1-Tyr323) - LS-G140037

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.3 kDa

Price:

10 µg/$344; 50 µg/$584

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