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Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Gene Name: | aldo-keto reductase family 1, member A1 (aldehyde reductase) |
Synonyms: | AKR1A1, ALDR1, Aldehyde reductase, Alcohol dehydrogenase, ARM, DD3, Dihydrodiol dehydrogenase 3, ALR |
Target Sequences: | NM_006066 NP_006057.1 P14550 |
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