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AKAP10
A kinase (PRKA) anchor protein 10
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
| Gene Name: | A kinase (PRKA) anchor protein 10 |
| Synonyms: | AKAP10, AKAP-10, D-AKAP-2, PRKA10, D-AKAP2 |
| Target Sequences: | NM_007202 NP_009133.2 O43572 |
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