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AIF1 / IBA1

allograft inflammatory factor 1

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Gene Name: allograft inflammatory factor 1
Synonyms: AIF1, AIF-1, Em:AF129756.17, G1, IRT-1, Protein G1, IBA1, IRT1
Target Sequences: NM_004847 NP_004838.1 P55008

Publications (6)

1
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide. Wu LP, Ahmadvand D, Su J, Hall A, Tan X, Farhangrazi ZS, Moghimi SM. Nature communications. 2019 October;10:4635. [Full Text Article] [PubMed:31604928] [PMC:PMC6789111]
2
N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Arina I Ponomarenko, Anna A Tyrtyshnaia, Evgeny A Pislyagin, Inessa V Dyuizen, Ruslan M Sultanov, Igor V Manzhulo. Scientific reports. 2021 January;11:756. [Full Text Article] [PubMed:33436960] [PMC:PMC7804312]
3
Complex interaction of dietary fat and Alaskan bog blueberry supplementation influences manganese mediated neurotoxicity and behavioral impairments. Malabika Maulik , Swarup Mitra , McKenzie Sweeney, Brianna Lu, Barbara E Taylor, Abel Bult-Ito. Journal of functional foods. 2019 Feb;53:306-317. [Full Text Article] [PubMed:31558914] [PMC:PMC6761827]
4
Hippocampal Neurogenesis in Conditions of Chronic Stress Induced by Sciatic Nerve Injury in the Rat. Evgeniia Egorova, Anna Starinets, Anna Tyrtyshnaia, Arina Ponomarenko, Igor Manzhulo. Cells, tissues, organs. 2019 July;207:58-68. [Full Text Article] [PubMed:31284284]
5
Spontaneous neoplasia in captive syngnathid species: A retrospective case series (2003-2014) and literature review. Daniela Denk, Ranieri Verin, Lorenzo Ressel, Eleanor Lewis, Mark F Stidworthy. Journal of fish diseases. 2020 August;43:929-939. [Full Text Article] [PubMed:32557754] Related Antibodies: LS-B2402.
6
Neoplastic pleural effusion and intrathoracic metastasis of a scapular osteosarcoma in a dog: a multidisciplinary integrated diagnostic approach. Luis Mesquita, Jeremy Mortier, Lorenzo Ressel, Riccardo Finotello, Paolo Silvestrini, Martina Piviani. Veterinary clinical pathology. 2017 June;46:337-343. [Full Text Article] [PubMed:28370186] Related Antibodies: LS-B2402.
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Proteins (20)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (2)
Recombinant (17)
AIF1 / IBA1 (20)
No (20)
6His, C-terminus (2)
6His, N-terminus (1)
GST (1)
His (6)
His, N-Terminal (2)
His-GST (1)
His-SUMO (2)
His-T7 (1)
Myc-DDK (Flag) (3)
Guinea pig (1)
Human (13)
Mouse (2)
Rat (3)
293T Cells (1)
E. coli (13)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Yeast (1)
Purified (2)
Low endotoxin level (3)
AIF1 / IBA1 Protein
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E. coli
His
20.9 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
AIF1 / IBA1 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
AIF1 / IBA1 Protein - Recombinant Allograft Inflammatory Factor 1 By SDS-PAGE
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E. coli
His
18.3 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
AIF1 / IBA1 Protein - Recombinant Allograft Inflammatory Factor 1 By SDS-PAGE
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E. coli
His
12.8 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
AIF1 / IBA1 Protein
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E. coli
None
50 µg/$472; 10 µg/$286; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,761
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E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.7kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
AIF1 / IBA1 Protein - Purified recombinant protein AIF1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
10.3 kDa
20 µg/$1,107
AIF1 / IBA1 Protein
Select
E. coli
6His, N-terminus
17 kDa
10 µg/$265; 100 µg/$365; 200 µg/$484; 50 µg/$315
AIF1 / IBA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
10.3 kDa
20 µg/$150
AIF1 / IBA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
10.3 kDa
100 µg/$494
Select
HEK 293 Cells
His, N-Terminal
~17 kDa
200 µl/$283
AIF1 / IBA1 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
His, N-Terminal
16.7 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432
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E. coli
145 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.06 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
AIF1 / IBA1 Protein
Select
E. coli
His-SUMO
32.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
AIF1 / IBA1 Protein
Select
E. coli
His-SUMO
32.69 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
AIF1 / IBA1 Protein - Recombinant  Allograft Inflammatory Factor 1 By SDS-PAGE
Select
E. coli
His-T7
20.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
AIF1 / IBA1 Protein - Recombinant Allograft Inflammatory Factor 1 By SDS-PAGE
Select
E. coli
His-GST
46.8 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
AIF1 / IBA1 Protein - 12.5% SDS-PAGE of human AIF1 stained with Coomassie Blue
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Wheat Germ Extract
GST
41.91 kDa
10 µg/$479; 25 µg/$670
AIF1 / IBA1 Protein
Select
Yeast
His
18.7 kD
1 mg/$1,683; 100 µg/$499; 20 µg/$364
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.7 kDa
100 µg/$281; 20 µg/$251
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).