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Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
Gene Name: | axin interactor, dorsalization associated |
Synonyms: | AIDA, C1orf80, RP11-378J18.7 |
Target Sequences: | NM_022831 NP_073742.2 Q96BJ3 |
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