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AICDA / AID

activation-induced cytidine deaminase

Activation-induced cytidine deaminase (AICDA) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. AICDA is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although AICDA is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.

Gene Name: activation-induced cytidine deaminase
Synonyms: AICDA, AID, ARP2, CDA2, Cytidine aminohydrolase, HIGM2
Target Sequences: NM_020661 NP_065712.1 Q9GZX7

Publications (3)

1
Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development. McCann KJ, Ashton-Key M, Smith K, Stevenson FK, Ottensmeier CH. Blood. 2009 113:4677-80. (IHC; Human) [PubMed:19096008] Related Antibodies: LS-B16.
2
Activation-induced cytidine deaminase expression in diffuse large B-cell lymphoma with a paracortical growth pattern: a lymphoma of possible interfollicular large B-cell origin. Aguilera NS, Auerbach A, Barekman CL, Lichy J, Abbondanzo SL. Archives of pathology & laboratory medicine. 2010 134:449-56. (IHC-P; Human) [PubMed:20196672] Related Antibodies: LS-C34861.
3
The BRCT domain of PARP-1 is required for immunoglobulin gene conversion. Paddock MN, Buelow BD, Takeda S, Scharenberg AM. PLoS biology. 2010 8:e1000428. (WB; Chicken) [Full Text Article] [PubMed:20652015] [PMC:PMC2907289] Related Antibodies: LS-C34861.

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Antibodies (33)
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AICDA / AID (42)
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AICDA / AID Antibody - Anti-AICDA antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
AICDA / AID Antibody - Anti-AICDA antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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AICDA / AID Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$565
AICDA / AID Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
IHC, IHC-P
Unconjugated
50 µl/$460
AICDA / AID Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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AICDA / AID Rat anti-Human Monoclonal (Asp191) Antibody
Human
WB
Unconjugated
100 µl/$702
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AICDA / AID Mouse anti-Human Monoclonal Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$702
Select
AICDA / AID Rabbit anti-Human Monoclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$688
AICDA / AID Antibody
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AICDA / AID Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
AICDA / AID Antibody - Antibody (0.1 ug/ml) staining of Human Tonsil lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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AICDA / AID Goat anti-Human Polyclonal (aa8-19) Antibody
Hamster, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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AICDA / AID Rat anti-Human Monoclonal (EK2-5G9) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
50 µg/$310
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$557
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AICDA / AID Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
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AICDA / AID Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, ICC, WB
Unconjugated
100 µg/$649
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AICDA / AID Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
0.1 mg/$379
AICDA / AID Antibody - Western blot All Lanes: AICDA antibody at 10 ug/ml+ Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 24,23 kDa Observed band size: 24 kDa
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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AICDA / AID Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
AICDA / AID Antibody - Western Blot analysis of extracts from Hela, HepG2 cells using AICDA Antibody.
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
AICDA / AID Antibody - Western blot analysis of AICDA using COLO205 whole lysates.
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
AICDA / AID Antibody - Western blot of AICDA antibody at 1:500 dilution. Lane 1: MCF-7 whole cell lysate. Lane 2: sp2/0 whole cell lysate. Lane 3: PC12 whole cell lysate.
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
AICDA / AID Antibody - Western blot of AICDA antibody at 1:500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: PC12 whole cell lysate.
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AICDA / AID Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
AICDA / AID Antibody - Western blot analysis of AID expression in HEK293T (A); PC12 (B) whole cell lysates.
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AICDA / AID Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Dog, Rat, Human
WB
Unconjugated
100 µl/$299
AICDA / AID Antibody - Western blot analysis of AID expression in MCF7 (A); NS-1 (B); PC12 (C) whole cell lysates.
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AICDA / AID Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
Select
AICDA / AID Rabbit anti-Human Polyclonal (HRP) Antibody
Rabbit, Mouse, Dog, Rat, Pig, Horse, Human
IHC
HRP Conjugated
100 µl/$469
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AICDA / AID Rabbit anti-Human Polyclonal (Biotin) Antibody
Rabbit, Mouse, Dog, Rat, Pig, Horse, Human
IHC
Biotin Conjugated
100 µl/$469
Viewing 1-25 of 42 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).