AGTR1 / AT1 Receptor

angiotensin II receptor, type 1

Type 1 Angiotensin Receptors (AT1A and AT1B) mediate the major cardiovascular effects of angiotensin II, controlling blood pressure and volume by regulating cell growth, vascular contraction, inflammatory responses, and salt and water retention. Stimulation of AT1 receptors by Ang II activates phospholipase C beta, resulting in increased intracellular calcium and inositol 1, 4, 5-triphosphate concentrations, and activatesthe mitogen-activated protein kinases, such as extracellular regulated kinases, by way of Src and Ras as well as the JAK/STAT pathways. AT1 knock-out mice have lower blood pressure than wild type mice and lose normal pressor response to exogenous Ang II. AT1B differs from AT1A in its mRNA tissue distribution and in the 5' untranslated region. AT1 blockers have become widely used in the treatment of hypertension and may offer benefits other than blood pressure reduction.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

AGTR1 / AT1 Receptor (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His,N-terminus + GST (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Rat (1)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

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Human AGTR1 / AT1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79378

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.9 kDa

Price:

20 µg/$150

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Rat AGTR1 / AT1 Receptor Protein (Recombinant His,N-terminus + GST) (aa263-359) - LS-G24415

Source:

E. coli

Tag:

His,N-terminus + GST

Molecular Weight:

40.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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Human AGTR1 / AT1 Receptor Protein (Recombinant 6His, N-terminus) (aa297-359) - LS-G22783

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

9.2 kD

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human AGTR1 / AT1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79382

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.9 kDa

Price:

20 µg/$150

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Human AGTR1 / AT1 Receptor Protein (Recombinant GST, N-terminus) (aa250-359) - LS-G57732

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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AGTR1 / AT1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109057

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.9 kDa

Price:

100 µg/$494

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AGTR1 / AT1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116385

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.9 kDa

Price:

100 µg/$494

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