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AGTR1 / AT1 Receptor

angiotensin II receptor, type 1

Type 1 Angiotensin Receptors (AT1A and AT1B) mediate the major cardiovascular effects of angiotensin II, controlling blood pressure and volume by regulating cell growth, vascular contraction, inflammatory responses, and salt and water retention. Stimulation of AT1 receptors by Ang II activates phospholipase C beta, resulting in increased intracellular calcium and inositol 1, 4, 5-triphosphate concentrations, and activatesthe mitogen-activated protein kinases, such as extracellular regulated kinases, by way of Src and Ras as well as the JAK/STAT pathways. AT1 knock-out mice have lower blood pressure than wild type mice and lose normal pressor response to exogenous Ang II. AT1B differs from AT1A in its mRNA tissue distribution and in the 5' untranslated region. AT1 blockers have become widely used in the treatment of hypertension and may offer benefits other than blood pressure reduction.

Gene Name: angiotensin II receptor, type 1
Family/Subfamily: GPCR , Angiotensin
Synonyms: AGTR1, AG2S, AGTR1A, AGTR1B, Angiotensin II type-1 receptor, Ang ii receptor type 1a, Angiotensin receptor 1, Angiotensin receptor 1a, Angiotensin receptor 1B, AT1R, AT1 receptor, At1a receptor, AT1B, AT1AR, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1, At1a, At1b receptor, AT1BR, Type-1 angiotensin II receptor
Target Sequences: NM_000685 NP_000676.1 P30556

Publications (3)

1
A Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity Responds Well to Renal Denervation. Li D, Wang Q, Zhang Y, Li D, Yang D, Wei S, Su L, Ye T, Zheng X, Peng K, Zhang L, Zhang Y, Yang Y, Ma S. American journal of hypertension. 2016 29:63-72. (WB; Human) [Full Text Article] [PubMed:25958303] Related Antibodies: LS-C54459.
2
The Identification of the Biomarkers of Sheng-Ji Hua-Yu Formula Treated Diabetic Wound Healing Using Modular Pharmacology. Jing-Si Jiang, Ying Zhang, Ying Luo, Yi Ru, Yue Luo, Xiao-Ya Fei, Jian-Kun Song, Xiao-Jie Ding, Zhan Zhang, Dan Yang, Shuang-Yi Yin, Hui-Ping Zhang, Tai-Yi Liu, Bin Li, Le Kuai. Frontiers in pharmacology. 2021 December;12:726158. [Full Text Article] [PubMed:34867329] [PMC:PMC8636748]
3
Apelin retards the progression of diabetic nephropathy. Day RT, Cavaglieri RC, Feliers D. American journal of physiology. Renal physiology. 2013 Mar;304:F788-800. [Full Text Article] [PubMed:23303408] [PMC:PMC3602700] Related Antibodies: LS-B4614.

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Products
ELISA Kits (23)
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AGTR1 / AT1 Receptor (23)
Human (9)
Mouse (1)
Rat (4)
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Serum (11)
Tissue Homogenates (7)
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$750
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AGTR1 / AT1 Receptor ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AGTR1 / AT1 Receptor ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
AGTR1 / AT1 Receptor ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
AGTR1 / AT1 Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
AGTR1 / AT1 Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
AGTR1 / AT1 Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
AGTR1 / AT1 Receptor ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).