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AGTR1 / AT1 Receptor

angiotensin II receptor, type 1

Type 1 Angiotensin Receptors (AT1A and AT1B) mediate the major cardiovascular effects of angiotensin II, controlling blood pressure and volume by regulating cell growth, vascular contraction, inflammatory responses, and salt and water retention. Stimulation of AT1 receptors by Ang II activates phospholipase C beta, resulting in increased intracellular calcium and inositol 1, 4, 5-triphosphate concentrations, and activatesthe mitogen-activated protein kinases, such as extracellular regulated kinases, by way of Src and Ras as well as the JAK/STAT pathways. AT1 knock-out mice have lower blood pressure than wild type mice and lose normal pressor response to exogenous Ang II. AT1B differs from AT1A in its mRNA tissue distribution and in the 5' untranslated region. AT1 blockers have become widely used in the treatment of hypertension and may offer benefits other than blood pressure reduction.

Gene Name: angiotensin II receptor, type 1
Family/Subfamily: GPCR , Angiotensin
Synonyms: AGTR1, AG2S, AGTR1A, AGTR1B, Angiotensin II type-1 receptor, Ang ii receptor type 1a, Angiotensin receptor 1, Angiotensin receptor 1a, Angiotensin receptor 1B, AT1R, AT1 receptor, At1a receptor, AT1B, AT1AR, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1, At1a, At1b receptor, AT1BR, Type-1 angiotensin II receptor
Target Sequences: NM_000685 NP_000676.1 P30556

Publications (3)

1
A Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity Responds Well to Renal Denervation. Li D, Wang Q, Zhang Y, Li D, Yang D, Wei S, Su L, Ye T, Zheng X, Peng K, Zhang L, Zhang Y, Yang Y, Ma S. American journal of hypertension. 2016 29:63-72. (WB; Human) [Full Text Article] [PubMed:25958303] Related Antibodies: LS-C54459.
2
The Identification of the Biomarkers of Sheng-Ji Hua-Yu Formula Treated Diabetic Wound Healing Using Modular Pharmacology. Jing-Si Jiang, Ying Zhang, Ying Luo, Yi Ru, Yue Luo, Xiao-Ya Fei, Jian-Kun Song, Xiao-Jie Ding, Zhan Zhang, Dan Yang, Shuang-Yi Yin, Hui-Ping Zhang, Tai-Yi Liu, Bin Li, Le Kuai. Frontiers in pharmacology. 2021 December;12:726158. [Full Text Article] [PubMed:34867329] [PMC:PMC8636748]
3
Apelin retards the progression of diabetic nephropathy. Day RT, Cavaglieri RC, Feliers D. American journal of physiology. Renal physiology. 2013 Mar;304:F788-800. [Full Text Article] [PubMed:23303408] [PMC:PMC3602700] Related Antibodies: LS-B4614.

☰ Filters
Antibodies (41)
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AGTR1 / AT1 Receptor (71)
Human (41)
Mouse (20)
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Chimpanzee (3)
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aa263-359 (8)
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AGTR1 / AT1 Receptor Antibody - Anti-AGTR1 antibody IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
AGTR1 / AT1 Receptor Antibody - Antibody (0.3 ug/ml) staining of Mouse Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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AGTR1 / AT1 Receptor Goat anti-Human Polyclonal (Internal Region) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
AGTR1 / AT1 Receptor Antibody - AGTR1 antibody IHC-paraffin. IHC(P): Human Mammary Cancer Tissue.
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal (aa1-28) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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AGTR1 / AT1 Receptor Sheep anti-Mouse Polyclonal (aa297-359) Antibody
Mouse, Rat
ELISA, IP, WB
Unconjugated
250 µg/$411
AGTR1 / AT1 Receptor Antibody - Immunohistochemistry of paraffin-embedded human heart tissue using AGTR1 Antibody at dilution of 1:100
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
AGTR1 / AT1 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
40.9 kDa
20 µg/$150
AGTR1 / AT1 Receptor Protein - Recombinant  Angiotensin II Receptor 1 By SDS-PAGE
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E. coli
His,N-terminus + GST
40.9 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
AGTR1 / AT1 Receptor Protein
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Yeast
6His, N-terminus
9.2 kD
100 µg/$570; 20 µg/$395; 1 mg/$1,973
AGTR1 / AT1 Receptor Antibody
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
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AGTR1 / AT1 Receptor Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Rat, Pig, Human
ELISA, WB
Unconjugated
100 µl/$801
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AGTR1 / AT1 Receptor Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Rat, Pig, Human
ELISA, WB
Unconjugated
100 µg/$832
AGTR1 / AT1 Receptor Antibody - AGTR1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal (aa37-86) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
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AGTR1 / AT1 Receptor Chicken anti-Rat Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Rat, Pig, Human
ELISA, WB
Unconjugated
100 µg/$832
AGTR1 / AT1 Receptor Antibody - Western blot of AT1 antibody
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal (80-160 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AGTR1 / AT1 Receptor Antibody - 1:100 staining human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
AGTR1 / AT1 Receptor Antibody - Peptide - + Immunofluorescence analysis of MCF-7 cells, using AGTR1 antibody.
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AGTR1 / AT1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
AGTR1 / AT1 Receptor Antibody - Western blot of AGTR1 / AT1 Receptor antibody.
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AGTR1 / AT1 Receptor Rabbit anti-Rat Polyclonal (aa263-359) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
AGTR1 / AT1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$750
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AGTR1 / AT1 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Select
293T Cells
Myc-DDK (Flag)
40.9 kDa
20 µg/$150
AGTR1 / AT1 Receptor ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
Viewing 1-25 of 71 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).