AGRN / Agrin

agrin

Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homestasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.Isoform 2: transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.Agrin N-terminal 110 kDa subunit: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling.

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

AGRN / Agrin (7)

Publications

No (7)

Tag

6His, N-terminus (1)

His (1)

His, N-Terminal (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human AGRN / Agrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81348

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

214.7 kDa

Price:

20 µg/$215

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Human AGRN / Agrin Protein (Recombinant 6His, N-terminus) (aa1856-2045) - LS-G13615

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

64.2 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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Mouse AGRN / Agrin Protein (Recombinant His, N-Terminal) (aa1130-1401) - LS-G24268

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.7 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Rat AGRN / Agrin Protein (Recombinant His-T7) (aa1206-1475) - LS-G13616

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.4 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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AGRN / Agrin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103597

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

214.7 kDa

Price:

100 µg/$710

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Human AGRN / Agrin Protein (Recombinant His) (aa311-459) - LS-G140974

Source:

E. coli

Sequence Length:

148 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

16.39 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human AGRN / Agrin Protein (Recombinant His, N-Terminal) (Pro1329-Cys1548) - LS-G133289

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26.8kDa

Price:

10 µg/$262; 50 µg/$339; 200 µg/$642; 100 µg/$512; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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