AGRN / Agrin

agrin

Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homestasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.Isoform 2: transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.Agrin N-terminal 110 kDa subunit: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling.

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Products

Antibodies (53)

Type

Primary (53)

Target

AGRN / Agrin (53)

Reactivity

Human (27)

Mouse (23)

Rat (23)

Application

IHC (7)

IHC-P (2)

WB (44)

ELISA (5)

ICC (7)

IF (1)

Peptide-ELISA (1)

Host

rabbit (43)

mouse (10)

Product Group

IHCPlus (2)

Isotype

IgG (8)

IgG1 (8)

IgG2a (2)

Clonality

monoclonal mc (10)

polyclonal pc (43)

Clone

AGR 131 (1)

Agr247 (1)

Agr-33 (1)

Format

APC (4)

APC Conjugated (5)

Biotin Conjugated (6)

Cy3 Conjugated (4)

Cy7 Conjugated (4)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (5)

Unconjugated (17)

Epitope

aa1130-1401 (8)

aa1206-1475 (8)

aa1856-2045 (8)

C-Terminus (6)

N-Terminus (1)

Publications

No (53)

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AGRN / Agrin Antibody (aa1856-2045) LS-B15259

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal (aa1856-2045) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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AGRN / Agrin Antibody (N-Terminus) LS-C137122

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µl/$332

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AGRN / Agrin Antibody LS-C402607

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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AGRN / Agrin Antibody (C-Terminus) LS-C11829

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat

Applications:

ICC, WB

Format:

Unconjugated

Price:

50 µg/$668; 200 µg/$1,027

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AGRN / Agrin Antibody (aa1130-1401) LS-C374094

Antibody:

AGRN / Agrin Rabbit anti-Mouse Polyclonal (aa1130-1401) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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AGRN / Agrin Antibody (aa1130-1401, PE) LS-C723467

Antibody:

AGRN / Agrin Rabbit anti-Mouse Polyclonal (aa1130-1401) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

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AGRN / Agrin Antibody (aa1130-1401, Cy3) LS-C700384

Antibody:

AGRN / Agrin Rabbit anti-Mouse Polyclonal (aa1130-1401) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

• Unconjugated
• PE
• Cy3

• Unconjugated
• PE
• Cy3

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AGRN / Agrin Antibody (C-Terminus, clone Agr-33) LS-C63140

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (C-Terminus) (Agr-33) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC

Format:

Unconjugated

Price:

50 µg/$400; 200 µg/$586

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AGRN / Agrin Antibody (C-Terminus, clone Agr247) LS-C63142

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (C-Terminus) (Agr247) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC

Format:

Unconjugated

Price:

50 µg/$393; 200 µg/$597

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AGRN / Agrin Antibody (aa1856-2045, Biotin) LS-C685703

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal (aa1856-2045) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279

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AGRN / Agrin Antibody LS-C778649

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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AGRN / Agrin Antibody (C-Terminus) LS-C353868

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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AGRN / Agrin Antibody LS-B15698

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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AGRN / Agrin Antibody (aa1206-1475, HRP) LS-C709404

Antibody:

AGRN / Agrin Rabbit anti-Rat Polyclonal (aa1206-1475) (HRP) Antibody

Reactivity:

Rat

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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AGRN / Agrin Antibody (aa1206-1475, FITC) LS-C692232

Antibody:

AGRN / Agrin Rabbit anti-Rat Polyclonal (aa1206-1475) (FITC) Antibody

Reactivity:

Rat

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

• HRP
• FITC

• HRP
• FITC

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AGRN / Agrin Antibody LS-C671895

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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AGRN / Agrin Antibody LS-C405862

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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AGRN / Agrin Antibody (C-Terminus) LS-C11825

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat

Applications:

ICC, WB

Format:

Unconjugated

Price:

200 µg/$968

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AGRN / Agrin Antibody (HRP) LS-C543371

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (HRP) Antibody

Reactivity:

Mouse, Rat

Applications:

ICC, WB

Format:

HRP Conjugated

Price:

100 µl/$1,172

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AGRN / Agrin Antibody (Biotin) LS-C523246

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (Biotin) Antibody

Reactivity:

Mouse, Rat

Applications:

ICC, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,172

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AGRN / Agrin Antibody (FITC) LS-C533287

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (FITC) Antibody

Reactivity:

Mouse, Rat

Applications:

ICC, WB

Format:

FITC Conjugated

Price:

100 µl/$1,172

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AGRN / Agrin Antibody (APC) LS-C515002

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (APC) Antibody

Reactivity:

Mouse, Rat

Applications:

ICC, WB

Format:

APC Conjugated

Price:

100 µl/$1,172

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AGRN / Agrin Antibody (PE) LS-C651485

Antibody:

AGRN / Agrin Mouse anti-Rat Monoclonal (PE) Antibody

Reactivity:

Mouse, Rat

Applications:

ICC, WB

Format:

PE Conjugated

Price:

100 µl/$1,172

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

Select

AGRN / Agrin Antibody LS-C807710

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

AGRN / Agrin Antibody LS-C342124

Antibody:

AGRN / Agrin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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