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Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.
Gene Name: | acylglycerol kinase |
Family/Subfamily: | Non-protein Kinase , Diacylglycerol kinase |
Synonyms: | AGK, Acylglycerol kinase, CATC5, HAGK, MTDPS10, Multi-substrate lipid kinase, MULK, HsMuLK |
Target Sequences: | NM_018238 NP_060708.1 Q53H12 |
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