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AGFG2 is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gene Name: | ArfGAP with FG repeats 2 |
Synonyms: | AGFG2, ArfGAP with FG repeats 2, HIV-1 Rev binding protein-like, HRBL, Nucleoporin, RAB-R, RABR |
Target Sequences: | NM_006076 NP_006067.3 O95081 |
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