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Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Gene Name: | amino-terminal enhancer of split |
Family/Subfamily: | Transcription factor |
Synonyms: | AES, AES-1, AES-2, Amino enhancer of split, ESP1, Groucho, GRG, Protein ESP1, TLE5, Protein GRG, gp130-associated protein GAM, GRG5 |
Target Sequences: | NM_198969 NP_945320.1 Q08117 |
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