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ADSL / Adenylosuccinate Lyase

adenylosuccinate lyase

Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: adenylosuccinate lyase
Synonyms: ADSL, Adenylosuccinate lyase, AMPS, ASASE, Adenylosuccinase
Target Sequences: NM_000026 NP_000017.1 P30566

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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
ADSL / Adenylosuccinate Lyase (8)
No (8)
GST (1)
His (2)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (1)
ADSL / Adenylosuccinate Lyase Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
ADSL / Adenylosuccinate Lyase Protein - Purified recombinant protein ADSL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
54.7 kDa
20 µg/$1,107
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E. coli
His
57 kDa
100 µg/$721
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293T Cells
Myc-DDK (Flag)
54.7 kDa
20 µg/$150
ADSL / Adenylosuccinate Lyase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48.1 kDa
20 µg/$150
ADSL / Adenylosuccinate Lyase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48.1 kDa
100 µg/$494
ADSL / Adenylosuccinate Lyase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
54.7 kDa
100 µg/$494
ADSL / Adenylosuccinate Lyase Protein - 12.5% SDS-PAGE of human ADSL stained with Coomassie Blue
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Wheat Germ Extract
GST
81.3 kDa
10 µg/$479; 25 µg/$670
Viewing 1-8 of 8 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).