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The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Gene Name: | adrenergic, beta, receptor kinase 2 |
Family/Subfamily: | Protein Kinase , GPRK |
Synonyms: | ADRBK2, BARK2, Beta-ARK-2, GRK3 |
Target Sequences: | NM_005160 NP_005151.2 P35626 |
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