ADRBK1 / GRK2

adrenergic, beta, receptor kinase 1

Beta-adrenergic receptor kinase (ADRBK1) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. The ADRBK1 gene spans approximately 23 kb and is composed of 21 exons. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy.

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Products

ELISA Kits (9)

Type

Cell-Based (2)

Cell-Based Phosphorylation (2)

Sandwich (5)

Target

ADRBK1 / GRK2 (9)

Reactivity

Human (6)

Mouse (5)

Rat (6)

Format

96-Well Microplate (4)

96-Well Strip Plate (5)

Publications

No (9)

Sample Type

Adherent Cell Cultures (4)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

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Mouse ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F32085

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human/Rat ADRBK1 / GRK2 (Cell-Based ELISA) ELISA Kit - LS-F3075

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F9317

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Mouse/Human/Rat Phospho-ADRBK1 / GRK2 (Ser685) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1720

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat ADRBK1 / GRK2 (Cell-Based ELISA) ELISA Kit - LS-F2028

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

Select

Human ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F32528

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F32529

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat ADRBK1 / GRK2 (Sandwich ELISA) ELISA Kit - LS-F49282

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse/Human/Rat Phospho-ADRBK1 / GRK2 (Ser29) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1172

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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