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ADRBK1 / GRK2
adrenergic, beta, receptor kinase 1
Beta-adrenergic receptor kinase (ADRBK1) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. The ADRBK1 gene spans approximately 23 kb and is composed of 21 exons. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy.
| Gene Name: | adrenergic, beta, receptor kinase 1 |
| Family/Subfamily: | Protein Kinase , GPRK |
| Synonyms: | ADRBK1, BARK1, Beta-ARK-1, BETA-ARK1, BARK, Betaark1, GRK2 |
| Target Sequences: | NM_001619 NP_001610.2 P25098 |
Publications (2)
1
Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins. Preuss I, Kurig B, Nrnberg B, Orth JH, Aktories K. Cellular signalling. 2009 21:551-8. (WB)
[PubMed:19135527]
2
Myocardial function after polarizing versus depolarizing cardiac arrest with blood cardioplegia in a porcine model of cardiopulmonary bypass. Aass T, Stangeland L, Moen CA, Salminen PR, Dahle GO, Chambers DJ, Markou T, Eliassen F, Urban M, Haaverstad R, Matre K, Grong K. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016 50:130-9. (WB; Human)
[PubMed:26843432]
[PMC:PMC4913873]
Related Antibodies: LS-C199027.
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ADRBK1 / GRK2
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ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer29) Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
ADRBK1 / GRK2 Mouse anti-Human Monoclonal (3F8) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$459
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer685) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (aa633-660) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ADRBK1 / GRK2 Mouse anti-Human Monoclonal (5D5) Antibody
Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$391; 100 µl/$489
ADRBK1 / GRK2 Mouse anti-Human Monoclonal (3F8) Antibody
Mouse, Rat, Primate, Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$541
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (Thr23) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (620-700 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (aa398-640) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
ADRBK1 / GRK2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$331
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer29) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$287; 100 µl/$431
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (pSer29) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (570-650 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (Ab-685) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
ADRBK1 / GRK2 Rabbit anti-Human Polyclonal (Val678) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
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product results
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