ADRB3

adrenoceptor beta 3

The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obesity.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

ADRB3 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ADRB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74752

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.3 kDa

Price:

20 µg/$150

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ADRB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123438

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.3 kDa

Price:

100 µg/$494

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Human ADRB3 Protein (Recombinant GST) (Full Length) - LS-G27379

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.9 kDa

Price:

2 µg/$439

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