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ADRB2

adrenoceptor beta 2, surface

ADRB2 is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

Gene Name: adrenoceptor beta 2, surface
Family/Subfamily: GPCR , Adrenergic
Synonyms: ADRB2, ADRB2R, Adrenoceptor beta 2, surface, ADRBR, B2AR, Beta-2 adrenoceptor, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, BETA2AR, BAR, Adrenergic beta-2 receptor, Catecholamine receptor
Target Sequences: NM_000024 NP_000015.1 P07550

Publications (4)

1
Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats. Rodrigues SF, Tran ED, Fortes ZB, Schmid-Schnbein GW. American journal of physiology. Heart and circulatory physiology. 2010 299:H25-35. [PubMed:20382857] [PMC:PMC2904131]
2
ß-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Limberg BJ, Andersson KE, Aura Kullmann F, Burmer G, de Groat WC, Rosenbaum JS. Cell and tissue research. 2011 317:107-16. (ICC, IHC-P; Human) [Full Text Article] [PubMed:20953633] [PMC:PMC3113530] Related Antibodies: LS-A2662.
3
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity. Hagberg CE, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina IG, Harms MJ, Shilkova O, Kozina V, Nedergaard J, Boucher J, Thorell A, Spalding KL. Cell reports. 2018 September;24:2746-2756. [Full Text Article] [PubMed:30184507] [PMC:PMC6137819] Related Antibodies: LS-C274967.
4
Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a beta2-adrenoceptor-independent mechanism. McCormick C, Alexandre L, Thompson J, Mutungi G. Journal of applied physiology (Bethesda, Md. : 1985). 2010 Dec;109:1716-27. [Full Text Article] [PubMed:20864554] Related Antibodies: LS-C54456.
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ADRB2 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
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Colorimetric - 450nm (TMB)
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1 Plate/$668
ADRB2 ELISA Kit
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96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$783
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Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ADRB2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ADRB2 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
ADRB2 ELISA Kit
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Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
ADRB2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$748
ADRB2 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ADRB2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ADRB2 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
ADRB2 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
ADRB2 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
ADRB2 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).