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Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Gene Name: | adrenoceptor alpha 2B |
Family/Subfamily: | GPCR , Adrenergic |
Synonyms: | ADRA2B, ADRA2RL1, Adrenergic receptor alpha 2B, Adrenoceptor alpha 2B, Alpha-2B adrenergic receptor, Alpha-2B-AR, Alpha-2BAR, ADRA2L1, ADRARL1, Alpha 2b, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Adrenergic alpha-2b receptor, Alpha2b, ALPHA2BAR |
Target Sequences: | NM_000682 NP_000673.2 P18089 |
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