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ADM / Adrenomedullin

adrenomedullin

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.

Gene Name: adrenomedullin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: ADM, Adrenomedullin, AM, Preproadrenomedullin
Target Sequences: NM_001124 NP_001115.1 P35318

Publications (2)

1
Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth. Akiko Nakayama, Kenneth Anthony Roquid, András Iring, Boris Strilic, Stefan Günther, Min Chen, Lee S Weinstein, Stefan Offermanns. The Journal of experimental medicine. 2023 Janurary;220: [Full Text Article] [PubMed:36374225] [PMC:PMC9665902] Related Antibodies: LS-B15534.
2
Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses. Sudikshya Paudel, Bangmin Liu, Magdalina J Cummings, Kelsey E Quinn, Fuller W Bazer, Kathleen M Caron, Xiaoqiu Wang. Biology of reproduction. 2021 October;105:876-891. [Full Text Article] [PubMed:34104954] [PMC:PMC8511665]

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Antibodies (105)
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ADM / Adrenomedullin (150)
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ADM / Adrenomedullin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$801
ADM / Adrenomedullin Protein - Recombinant Adrenomedullin By SDS-PAGE
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E. coli
6His, N-terminus
15.8 kDa
10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453
ADM / Adrenomedullin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
ADM / Adrenomedullin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ADM / Adrenomedullin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Pig
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$779
ADM / Adrenomedullin ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$779
ADM / Adrenomedullin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
ADM / Adrenomedullin Protein - Recombinant Adrenomedullin By SDS-PAGE
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E. coli
His
19.4 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
ADM / Adrenomedullin ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ADM / Adrenomedullin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
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ADM / Adrenomedullin Rabbit anti-Mouse Polyclonal (aa1-50) Antibody
Mouse
ELISA
Unconjugated
400 µg/$860
ADM / Adrenomedullin Antibody - Adrenomedullin staining in human lung cancer tissue. Paraffin-embedded human lung cancer tissue is stained with Adrenomedullin antibody used at 1:200 dilution.
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$432
ADM / Adrenomedullin Antibody - Western blot of recombinant ADM / Adrenomedullin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Mouse Polyclonal (aa24-171) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa1-52) Antibody
Human
ELISA
Unconjugated
400 µg/$941
ADM / Adrenomedullin Antibody - Western blot of recombinant ADM / Adrenomedullin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Dog Polyclonal (aa31-187) Antibody
Dog, Rat, Human
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
ADM / Adrenomedullin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
ADM / Adrenomedullin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ADM / Adrenomedullin Antibody - Western blot of recombinant ADM / Adrenomedullin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Cow Polyclonal (aa35-171) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589
ADM / Adrenomedullin Protein
Select
E. coli
His, N-Terminal
18.4 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
ADM / Adrenomedullin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
ADM / Adrenomedullin Antibody - Immunohistochemistry of paraffin-embedded human lung tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADM / Adrenomedullin Rabbit anti-Human Polyclonal (aa45-92) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ADM / Adrenomedullin Rabbit anti-Mouse Polyclonal (aa1-50) Antibody
Mouse
ICC, IHC
Unconjugated
50 µl/$860
Viewing 1-25 of 150 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).