ADGRG1 / GPR56

G protein-coupled receptor 56

Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. Required for normal cortical development and regulation of neuroprogenitor cells proliferation.

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Products

ELISA Kits (1)

Type

Sandwich (1)

Target

ADGRG1 / GPR56 (1)

Reactivity

Human (1)

Format

96-Well Microplate (1)

Publications

No (1)

Sample Type

Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

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Human ADGRG1 / GPR56 (Sandwich ELISA) ELISA Kit - LS-F49946

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

16 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$610

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