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ADGRG1 / GPR56

G protein-coupled receptor 56

Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. Required for normal cortical development and regulation of neuroprogenitor cells proliferation.

Gene Name: G protein-coupled receptor 56
Family/Subfamily: GPCR , Orphan-B
Synonyms: ADGRG1, BFPP, G-protein coupled receptor 56, GPR56, G protein-coupled receptor 56, TM7LN4, Protein TM7XN1, TM7XN1
Target Sequences: NM_005682 NP_005673.3 Q9Y653

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Products
Antibodies (25)
Primary (25)
ADGRG1 / GPR56 (25)
Human (25)
Chimpanzee (3)
Monkey (6)
Orangutan (3)
Rabbit (3)
IHC (6)
IHC-P (5)
WB (17)
ELISA (6)
IF (4)
Peptide-ELISA (3)
rabbit (23)
mouse (2)
Product Group
GPCR Database Antibodies (4)
IHCPlus (2)
PathPlus Cancer (2)
IgG (15)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (24)
1443CT377.65.29 (1)
APC Conjugated (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (14)
N-Terminus (6)
Cytoplasmic Domain (2)
220-300 aa, Internal (1)
Internal (1)
aa251-300 (1)
No (25)
ADGRG1 / GPR56 Antibody - Brain, Glioblastoma
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Cancer
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
ADGRG1 / GPR56 Antibody - Human, Brain: Formalin-Fixed Paraffin-Embedded (FFPE)
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Cancer
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
ADGRG1 / GPR56 Antibody - Anti-GPR56 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 4-32 ug/ml.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
ADGRG1 / GPR56 Antibody - Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE)
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Fast Shipping
ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
ADGRG1 / GPR56 Antibody - Immunohistochemistry Dilution at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
ADGRG1 / GPR56 Antibody - All lanes : Anti-GPR56 Antibody at 1:1000 dilution Lane 1: HeLa whole cell lysates Lane 2: U87-MG whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 78 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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ADGRG1 / GPR56 Mouse anti-Human Monoclonal (1443CT377.65.29) Antibody
Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
ADGRG1 / GPR56 Antibody - Immunofluorescence analysis of MCF7 cells, using GPR56 Antibody. The picture on the right is blocked with the synthesized peptide.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADGRG1 / GPR56 Antibody - GPR56 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
ADGRG1 / GPR56 Antibody - GPR56 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Rabbit, Human, Monkey, Chimpanzee, Orangutan
WB
HRP Conjugated
100 µl/$469
ADGRG1 / GPR56 Antibody - GPR56 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Rabbit, Human, Monkey, Chimpanzee, Orangutan
WB
Biotin Conjugated
100 µl/$469
ADGRG1 / GPR56 Antibody - GPR56 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Rabbit, Human, Monkey, Chimpanzee, Orangutan
WB
FITC Conjugated
100 µl/$469
ADGRG1 / GPR56 Antibody - Western blot of GPR56 antibody
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (220-300 aa, Internal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADGRG1 / GPR56 Antibody - Peptide - + Immunofluorescence analysis of MCF-7cells, using GPR56 antibody.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
ADGRG1 / GPR56 Antibody - 1:100 staining human lymph node tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal Antibody
Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
ADGRG1 / GPR56 Antibody - Western blot analysis of GPR56 expression in human brain (A) whole cell lysates.
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ADGRG1 / GPR56 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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ADGRG1 / GPR56 Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).