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EGF-Like Module Containing Mucin-Like Hormone Receptor-Like Sequence 4 (EMR4) is characterized as an Orphan-B GPCR with an unknown ligand. EMR4 has two epidermal growth factor-like domains in the extracellular region. The mouse homolog, FIRE, may be a useful marker of dendritic cell development. mEMR4 is the first EGF-TM7 receptor known to mediate the cellular interaction between myeloid cells and B cells.
Gene Name: | EMR4P / EMR4 / GPR127 / EGF-Like Module-Containing Mucin-Like Receptor 4 |
Family/Subfamily: | GPCR , Orphan-B |
Synonyms: | ADGRE4P |
Target Sequences: | AY181245 AAO27357.1 Q86SQ3 |
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