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6737 Mowry Ave
Newark, CA 94560
United States
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ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS3 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.
| Gene Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 3 |
| Family/Subfamily: | Protease , Metallopeptidase M12B |
| Synonyms: | ADAMTS3, ADAMTS-3, ADAM-TS 3, ADAMTS-4, ADAM-TS3, KIAA0366, Zinc metalloendopeptidase, PC II-NP, Procollagen II N-proteinase |
| Target Sequences: | NM_014243 NP_055058.2 O15072 |
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