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ADAMTS18 is a Metallopeptidase M12B type protease. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. Former prototype NM_139054.2 was temporarily suppressed because currently there is not sufficient data to support this transcript.
Gene Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 18 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAMTS18, ADAMTS-18, ADAM-TS 18, ADAM-TS18, ADAMTS21, KNO2 |
Target Sequences: | NM_199355 NP_955387.1 Q8TE60 |
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