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ADAM8
ADAM metallopeptidase domain 8
ADAM8 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
| Gene Name: | ADAM metallopeptidase domain 8 |
| Family/Subfamily: | Protease , Metallopeptidase M12B |
| Synonyms: | ADAM8, ADAM metallopeptidase domain 8, Cell surface antigen MS2, ADAM 8, MS2, CD156, CD156a antigen |
| Target Sequences: | NM_001109 NP_001100.3 P78325 |
Publications (3)
1
N-glycosylation regulates ADAM8 processing and activation. Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. The Journal of biological chemistry. 2014 289:33676-88. (WB; Human)
[Full Text Article]
[PubMed:25336660]
[PMC:PMC4246118]
Related Antibodies: LS-B4068.
2
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Das SG, Romagnoli M, Mineva ND, Barillé-Nion S, Jézéquel P, Campone M, Sonenshein GE. Breast cancer research : BCR. 2016 18:40. (WB; Human)
[Full Text Article]
[PubMed:27039296]
[PMC:PMC4818899]
Related Antibodies: LS-B4068.
3
ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg Á, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. EMBO molecular medicine. 2014 Feb;6:278-294. (IHC; Human)
[Full Text Article]
[PubMed:24375628]
[PMC:PMC3927960]
Related Antibodies: LS-B4068.
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ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADAM8 Rabbit anti-Mouse Polyclonal (aa145-493) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
ADAM8 Goat anti-Human Polyclonal (aa813-824) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ADAM8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADAM8 Rabbit anti-Human Polyclonal (aa70-119) Antibody
Human
WB
Unconjugated
100 µl/$424
E. coli
His, N-Terminal
42.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ADAM8 Mouse anti-Human Monoclonal (aa158-653) Antibody
Human
ELISA, Flo, IP, WB
Unconjugated
500 µg/$1,099
ADAM8 Rabbit anti-Human Polyclonal (aa371-587) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ADAM8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$431
ADAM8 Mouse anti-Human Monoclonal (2C1F3) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µg/$459
ADAM8 Mouse anti-Human Monoclonal (3B10D7) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$459
ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
ADAM8 Rabbit anti-Human Polyclonal (aa126-155) Antibody
Human
WB
Unconjugated
200 µl/$734
ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
ADAM8 Rabbit anti-Human Polyclonal (aa126-155) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
ADAM8 Rabbit anti-Human Polyclonal (aa126-155) Antibody
Human
WB
Unconjugated
400 µl/$393
ADAM8 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
ADAM8 Mouse anti-Human Monoclonal (aa158-653) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$930; 500 µg/$1,795
ADAM8 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
ADAM8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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