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ADAM28 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants.
Gene Name: | ADAM metallopeptidase domain 28 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAM28, Disintegrin 1, Dtgn1, ADAM 28, EMDCII, EMDC II, MDC-L, MDC-Ls, MDCL, MDC-Lm |
Target Sequences: | NM_014265 NP_055080.2 Q9UKQ2 |
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