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Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Gene Name: | adenosine deaminase |
Synonyms: | ADA, Adenosine deaminase, ADA1, Adenosine aminohydrolase |
Target Sequences: | NM_000022 NP_000013.2 P00813 |
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