ACY1 / Aminoacylase 1

aminoacylase 1

ACY1 / Aminoacylase 1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

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Products

ELISA Kits (7)

Type

Custom (3)

Sandwich (4)

Target

ACY1 / Aminoacylase 1 (7)

Reactivity

Human (4)

Mouse (1)

Rat (1)

Pig (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

Publications

No (7)

Sample Type

Cell Culture Supernatants (1)

Plasma (4)

Serum (4)

Tissue Homogenates (3)

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Human ACY1 / Aminoacylase 1 (Sandwich ELISA) ELISA Kit - LS-F8218

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Mouse ACY1 / Aminoacylase 1 (Sandwich ELISA) ELISA Kit - LS-F19617

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human ACY1 / Aminoacylase 1 (Sandwich ELISA) ELISA Kit - LS-F19620

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Rat ACY1 / Aminoacylase 1 (Custom ELISA) ELISA Kit - LS-F19618

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Pig ACY1 / Aminoacylase 1 (Custom ELISA) ELISA Kit - LS-F19619

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human ACY1 / Aminoacylase 1 (Sandwich ELISA) ELISA Kit - LS-F31999

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human ACY1 / Aminoacylase 1 (Custom ELISA) ELISA Kit - LS-F50153

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$610

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