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ACVR2 / ACVR2A

activin A receptor, type IIA

ACVR2 / ACVR2A is a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Gene Name: activin A receptor, type IIA
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: ACVR2A, ACTRIIA, Activin receptor type IIA, ACTRII, Activin A receptor type II, Activin receptor type-2A, ACTR-IIA, Activin A receptor, type II, Activin A receptor, type IIA, ACVR2
Target Sequences: NM_001616 NP_001607.1 P27037

Publications (1)

1
Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and western single blotting. Christian Reichel, Letizia Farmer, Günter Gmeiner, Katja Walpurgis, Mario Thevis. Drug testing and analysis. 2018 June;10:927-937. [Full Text Article] [PubMed:29193906]

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Products
Antibodies (80)
Primary (80)
ACVR2 / ACVR2A (80)
Human (50)
Mouse (39)
Rat (15)
Bovine (20)
Cow (16)
Dog (3)
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Guinea pig (3)
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IHC (18)
IHC-P (10)
WB (77)
Flo (1)
ELISA (15)
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Peptide-ELISA (2)
rabbit (71)
mouse (7)
goat (2)
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IgG (20)
IgG1 (6)
IgG2a (1)
monoclonal mc (7)
polyclonal pc (73)
12K5 (1)
OTI1F2 (2)
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aa20-135 (24)
aa192-325 (8)
aa326-485 (8)
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C-Terminus (4)
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aa20-140 (2)
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aa10-59 (1)
aa2-29 (1)
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No (80)
ACVR2 / ACVR2A Antibody - Anti-ACVR2A antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa2-29) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
ACVR2 / ACVR2A Antibody - Anti-ALK-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
ACVR2 / ACVR2A Antibody - Mouse Acvr2a Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The Acvr2a antibody detected the Acvr2a protein (arrow).
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa22-49) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
ACVR2 / ACVR2A Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa20-140) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (Extracellular Domain) (APC) (12K5) Antibody
Human
Flo
APC Conjugated
100 Tests/$896
ACVR2 / ACVR2A Antibody - Western blot analysis of lysates from rat kidney, using ACTR-IIA antibody.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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ACVR2 / ACVR2A Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, IHC, IP, Neut, WB
Unconjugated
100 µg/$962
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using ACVR2A Polyclonal Antibody at dilution of 1:20.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ACVR2 / ACVR2A Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa45-305) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACVR2 / ACVR2A Antibody - 1:100 staining human urothelial carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ACVR2 / ACVR2A Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa267-513) Antibody
Mouse, Bovine, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
ACVR2 / ACVR2A Antibody - Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-ACVR2A mouse monoclonal antibody.This figure shows negative staining. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (OTI1F2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ACVR2 / ACVR2A Antibody - Immunohistochemical staining of paraffin-embedded Human thyroid tissue within the normal limits using anti-ACVR2A mouse monoclonal antibody.This figure shows negative staining. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (Carrier-free) (OTI1F2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using ACVR2A Polyclonal Antibody at dilution of 1:20.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded mouse kidney tissue.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ACVR2 / ACVR2A Antibody - Immunohistochemistry of paraffin-embedded human skin using antibody at 1:100 dilution.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa20-140) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
ACVR2 / ACVR2A Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ACVR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (OTI5D1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ACVR2 / ACVR2A Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ACVR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (Carrier-free) (OTI5D1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ACVR2 / ACVR2A Antibody
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
ACVR2 / ACVR2A Antibody - ACVR2A was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- ACVR2A Antigen Affinity purified polyclonal antibody
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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ACVR2 / ACVR2A Rabbit anti-Mouse Polyclonal (aa22-49) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACVR2 / ACVR2A Antibody - Western blot analysis of HeLa cell, using ACVR2A Polyclonal Antibody at dilution of 1:400.
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ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).