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ACVR2 / ACVR2A
activin A receptor, type IIA
ACVR2 / ACVR2A is a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
| Gene Name: | activin A receptor, type IIA |
| Family/Subfamily: | Protein Kinase , Activin/TGFb |
| Synonyms: | ACVR2A, ACTRIIA, Activin receptor type IIA, ACTRII, Activin A receptor type II, Activin receptor type-2A, ACTR-IIA, Activin A receptor, type II, Activin A receptor, type IIA, ACVR2 |
| Target Sequences: | NM_001616 NP_001607.1 P27037 |
Publications (1)
1
Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and western single blotting. Christian Reichel, Letizia Farmer, Günter Gmeiner, Katja Walpurgis, Mario Thevis. Drug testing and analysis. 2018 June;10:927-937. [Full Text Article]
[PubMed:29193906]
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Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa2-29) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.35kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
Wheat Germ Extract
GST
84.2 kDa
2 µg/$439
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa22-49) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa20-140) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.8 kDa
100 µg/$793; 1 mg/$4,191
ACVR2 / ACVR2A Mouse anti-Human Monoclonal (Extracellular Domain) (APC) (12K5) Antibody
Human
Flo
APC Conjugated
100 Tests/$896
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
293T Cells
Myc-DDK (Flag)
57.85 kDa
20 µg/$150
ACVR2 / ACVR2A Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, IHC, IP, Neut, WB
Unconjugated
100 µg/$962
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Neuroscience
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa45-305) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa267-513) Antibody
Mouse, Bovine, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
HEK 293 Cells
Myc-DDK (Flag)
57.85 kDa
100 µg/$494
ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (OTI1F2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (Carrier-free) (OTI1F2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal (aa20-140) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
ACVR2 / ACVR2A Mouse anti-Human Monoclonal (aa214-513) (OTI5D1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ACVR2 / ACVR2A Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
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