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ACVR1C / ALK7
activin A receptor, type IC
ALK7, a Activin/TGFb type protein kinase, is a member of the Nodal signaling pathway, which is implicated in developmental events such as mesoderm formation and left-right axis specification. ALK7 is a type I receptor that has been shown to collaborate with activin receptor type 2B (ActRIIB). A constitutively active form of ALK7 has been shown to increase phosphorylation of Smad2, a receptor-regulated signaling protein which translocate to the nucleus to activate transcription. Smad3 also is believed to be a target of ALK7.
| Gene Name: | activin A receptor, type IC |
| Family/Subfamily: | Protein Kinase , Activin/TGFb |
| Synonyms: | ACVR1C, Activin receptor-like kinase 7, ACTR-IC, Activin receptor type IC, ACVRLK7, Activin receptor type-1C, ALK7, Activin A receptor, type IC, ALK-7 |
| Target Sequences: | NM_145259 NP_660302.2 Q8NER5 |
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