Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
Gene Name: | actinin, alpha 2 |
Synonyms: | ACTN2, Actinin, alpha 2, Alpha-actinin skeletal muscle, CMD1AA, F-actin cross-linking protein, Alpha-actinin-2 |
Target Sequences: | NM_001103 NP_001094.1 P35609 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.