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ACTA2 / Smooth Muscle Actin

actin, alpha 2, smooth muscle, aorta

ACTA2 / Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name:	actin, alpha 2, smooth muscle, aorta
Synonyms:	ACTA2, ACTVS, Alpha-actin-2, Alpha-cardiac actin, AAT6, Actin, aortic smooth muscle, ACTSA, Smooth Muscle Actin, MYMY5, SMA
Target Sequences:	NM_001613 NP_001604.1 P62736

Publications (11)

Infection of Human Retinal Pigment Epithelium with Chlamydia trachomatis. Boiko E, Maltsev D, Savicheva A, Shalepo K, Khusnutdinova T, Pozniak A, Kvetnoi I, Polyakova V, Suetov A. PloS one. 2015 10:e0141754. (IHC-P; Human) [Full Text Article] [PubMed:26536616] [PMC:PMC4633144]

Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response. Westendorp BF, Büller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR,. Cellular and molecular gastroenterology and hepatology. 2017 5:67-82. (WB; Human) [Full Text Article] [PubMed:29276753] Related Antibodies: LS-B3933.

Towards an in vitro fibrogenesis model of human vocal fold scarring. Graupp M, Rinner B, Frisch MT, Weiss G, Fuchs J, Sundl M, El-Heliebi A, Moser G, Kamolz LP, Karbiener M, Gugatschka M. European Archives of Oto-Rhino-Laryngology and Head & Neck. 2018 May;275:1211-1218. (Human) [Full Text Article] [PubMed:29520499] [PMC:PMC5893733] Related Antibodies: LS-B3933.

Excessive Production of Transforming Growth Factor ß1 Causes Mural Cell Depletion From Cerebral Small Vessels. Taisuke Kato, Yumi Sekine, Hiroaki Nozaki, Masahiro Uemura, Shoichiro Ando, Sachiko Hirokawa, Osamu Onodera. Frontiers in aging neuroscience. 2020 June;12:151. [Full Text Article] [PubMed:32581764] [PMC:PMC7283554]

Complete dependence on CD4+ cells in late asthmatic response, but limited contribution of the cells to airway remodeling in sensitized mice. Takeshi Nabe, Toyoko Morishita, Kouki Matsuya, Ayumu Ikedo, Masanori Fujii, Nobuaki Mizutani, Shin Yoshino. Journal of pharmacological sciences. 2011 July;116:373-83. [Full Text Article] [PubMed:21778663]

Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Mark A Chapman, Kavitha Mukund, Shankar Subramaniam, David Brenner, Richard L Lieber. American journal of physiology. Cell physiology. 2017 February;312:C131-C143. [Full Text Article] [PubMed:27881411] [PMC:PMC5336596] Related Antibodies: LS-C124868.

Characterization of a mouse model of hypereosinophilia-associated heart disease. Daniel R Prows, Andrea Klingler, William J Gibbons Jr, Shelli M Homan, Nives Zimmermann. American journal of physiology. Heart and circulatory physiology. 2019 August;317:H405-H414. [Full Text Article] [PubMed:31199184] [PMC:PMC6732473]

Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma. Joseph Ojo, Max Eisenbaum, Ben Shackleton, Cillian Lynch, Utsav Joshi, Nicole Saltiel, Andrew Pearson, Charis Ringland, Daniel Paris, Benoit Mouzon, Michael Mullan, Fiona Crawford, Corbin Bachmeier. Neurobiology of disease. 2021 Mar;;150:105237. [Full Text Article] [PubMed:33383188] [PMC:PMC8170787]

Impairment of cerebrovascular reactivity in response to hypercapnic challenge in a mouse model of repetitive mild traumatic brain injury. Cillian E Lynch, Maxwell Eisenbaum, Moustafa Algamal, Matilde Balbi, Scott Ferguson, Benoit Mouzon, Nicole Saltiel, Joseph Ojo, Ramon Diaz-Arrastia, Mike Mullan, Fiona Crawford, Corbin Bachmeier. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021 June;41:1362-1378. [Full Text Article] [PubMed:33050825] [PMC:PMC8142124]

Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel. Elle Koivunotko, Jasmi Snirvi, Arto Merivaara, Riina Harjumäki, Swarna Rautiainen, Minna Kelloniemi, Kirsi Kuismanen, Susanna Miettinen, Marjo Yliperttula, Raili Koivuniemi. Biomedicines. 2022 October;10: [Full Text Article] [PubMed:36289846] [PMC:PMC9599553] Related Antibodies: LS-B16663.

Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors. Shindu C Thomas, Tushar Madaan, Nitin S Kamble, Nabil A Siddiqui, Giovanni M Pauletti, Nalinikanth Kotagiri. Advanced healthcare materials. 2022 January;11:e2101487. [Full Text Article] [PubMed:34738725] [PMC:PMC8770579]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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