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ACSS2 / ACAS2

acyl-CoA synthetase short-chain family member 2

ACSS2 / ACAS2 is a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.

Gene Name: acyl-CoA synthetase short-chain family member 2
Synonyms: ACSS2, Acetate-CoA ligase, Acetyl-CoA synthetase, Acetate--CoA ligase, ACS, ACSA, ACAS2, ACECS, DJ1161H23.1, Acetate thiokinase, Acyl-activating enzyme
Target Sequences: NM_018677 NP_061147.1 Q9NR19

Publications (1)

1
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma. Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard E Davis, Pei Lin, P Leif Bergsagel, Elisabet E Manasanch, Stephen T C Wong, Nestor F Esnaola, Jenny C Chang, Robert Z Orlowski, Qing Yi, Jing Yang. The Breast : official journal of the European Society of Mastology. 2021 January;33:78-93e7. [Full Text Article] [PubMed:33406405] [PMC:PMC7799390] Related Antibodies: LS-C334743.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
ACSS2 / ACAS2 (6)
No (6)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
ACSS2 / ACAS2 Protein - 12.5% SDS-PAGE of human ACSS2 stained with Coomassie Blue
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Wheat Germ Extract
GST
94 kDa
10 µg/$479; 25 µg/$670
ACSS2 / ACAS2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ACSS2 / ACAS2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
78.4 kDa
20 µg/$150
ACSS2 / ACAS2 Protein - Purified recombinant protein ACSS2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
78.4 kDa
20 µg/$1,107
ACSS2 / ACAS2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
78.4 kDa
100 µg/$494
ACSS2 / ACAS2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).