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ACSL4 / FACL4

acyl-CoA synthetase long-chain family member 4

ACSL4 / FACL4 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.

Gene Name: acyl-CoA synthetase long-chain family member 4
Synonyms: ACSL4, Acyl-CoA synthetase 4, ACS4, FACL4, LACS4, LACS 4, Lignoceroyl-CoA synthase, MRX63, MRX68
Target Sequences: NM_004458 NP_004449.1 O60488

Publications (2)

1
Human cytomegalovirus inhibits apoptosis by proteasomal-mediated degradation of Bax at ER-mitochondrial contacts. Nagpal JK, Dasgupta S, Jadallah S, Chae YK, Ratovitski EA, Toubaji A, Netto GJ, Eagle T, Nissan A, Sidransky D, Trink B. Journal of virology. 2013 [PubMed:23487455] Related Antibodies: LS-C98511.
2
Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia. Kirkwood A Pritchard Jr, Xigang Jing, Michelle Teng, Clive Wells, Shuang Jia, Adeleye J Afolayan, Jason Jarzembowski, Billy W Day, Stephen Naylor, Martin J Hessner, G Ganesh Konduri, Ru-Jeng Teng. PloS one. 2022 August;17:e0269564. [Full Text Article] [PubMed:36018859] [PMC:PMC9417039] Related Antibodies: LS-B5818.

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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
ACSL4 / FACL4 (8)
No (8)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (6)
Human (6)
293T Cells (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (1)
ACSL4 / FACL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
74.3 kDa
20 µg/$150
ACSL4 / FACL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
79 kDa
20 µg/$215
ACSL4 / FACL4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ACSL4 / FACL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
74.3 kDa
100 µg/$494
ACSL4 / FACL4 Protein - Purified recombinant protein ACSL4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
74.3 kDa
20 µg/$1,107
ACSL4 / FACL4 Protein - Purified recombinant protein ACSL4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
79 kDa
20 µg/$1,107
ACSL4 / FACL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
79 kDa
100 µg/$710
ACSL4 / FACL4 Protein - 12.5% SDS-PAGE of human ACSL4 stained with Coomassie Blue
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Wheat Germ Extract
GST
100.8 kDa
2 µg/$439
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).