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Acid phosphatase 5 is an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. ACP5 is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. It is expressed at high levels by osteoclasts, macrophages and dendritic cells. Two forms circulating in human blood are derived from different cell types and have different functions. 5a is derived from macrophages and dendritic cells and is a marker of inflammatory conditions. 5b is derived from osteoclasts and is a marker of bone resorption.
Gene Name: | acid phosphatase 5, tartrate resistant |
Synonyms: | ACP5, SPENCDI, TrATPase, Type 5 acid phosphatase, Tartrate-resistant acid ATPase, TR-AP, TRACP5b |
Target Sequences: | NM_001611 NP_001602.1 P13686 |
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