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ACO2 / Aconitase 2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
Gene Name: | aconitase 2, mitochondrial |
Synonyms: | ACO2, ACONM, Aconitase 2, Aconitase 2, mitochondrial, Citrate hydro-lyase, ICRD |
Target Sequences: | NM_001098 NP_001089.1 Q99798 |
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